The metabolism of chrysene: the isolation of 3-methoxychrysene by methylation of the phenolic metabolite of chrysene from rat faeces.

As a result of the work of Levvy et al. (1948), it is no longer necessary to postulate a synthetic role for fl-glucuronidase in the body (Fishman, 1940) in order to explain the changes in the activity of the enzyme which can be produced in various organs. The view that ,B-glucuronidase is not involved in glucuronide synthesis (Levvy, 1948) receives support from the failure of saccharic acid to influence formation of o-aminophenylglucuronide bymouse-liver slices, and of f-glucuronidase preparations to effect condensation of glucuronic acid with o-aminophenol. Certain sex hormones are known to be excreted as glucuronides. The effect of administering saccharic acid on the metabolism of these compounds might repay investigation.